Insulin-like Growth Factor-1/Insulin Bypasses Pref-1/FA1-mediated Inhibition of Adipocyte Differentiation
نویسندگان
چکیده
منابع مشابه
Inhibition of adipocyte differentiation by insulin-like growth factor-binding protein-3.
Insulin-like growth factor-binding protein-3 (IGFBP-3) interacts with the type II nuclear receptors retinoid X receptor (RXR)alpha and retinoic acid receptor-alpha and modulates their transcriptional activity. Peroxisome proliferator-activated receptor (PPAR)gamma, a related nuclear receptor that dimerizes with RXRalpha, plays an important role in adipocyte differentiation. IGFBP-3 is regulated...
متن کاملA growth factor-repressible gene associated with protein kinase C- mediated inhibition of adipocyte differentiation
The conversion of determined adipoblasts to fully differentiated adipocytes requires appropriate environmental conditions. A strict dependence on cell confluence and a facilitation by glucocorticoid hormones have previously been described. We have found that agents that are capable of activating protein kinase C, such as basic fibroblast growth factor and phorbol esters, inhibit the differentia...
متن کاملConnective tissue growth factor inhibits adipocyte differentiation.
Adipocyte differentiation is a key process implicated in the pathogenesis of obesity and insulin resistance. Its regulation is triggered by a cascade of transcription factors, including the CCAAT/enhancer binding proteins (C/EBPs) and peroxisome proliferator-activated receptor-gamma (PPARgamma). Growth factors such as transforming growth factor-beta1 (TGF-beta1) are known to inhibit adipocyte d...
متن کاملInsulin activates the appearance of insulin-like growth factor II receptors on the adipocyte cell surface.
To evaluate the mechanism of insulin action to increase rat 125I-labeled insulin-like growth factor II (125I-IGF-II) binding to rat adipocytes, we raised a potent rabbit antiserum against purified IGF-II receptors from rat placental membranes. The antiserum elicited a positive reaction at a 1:5000 dilution against purified IGF-II receptor in an ELISA and markedly inhibited 125I-IGF-II binding t...
متن کاملInsulin-like growth factor-I regulates pro-B cell differentiation.
Progression of B-lymphocyte development in the bone marrow of postnatal mammals is marked by progressive rearrangement and expression of immunoglobulin (Ig) heavy- and light-chain genes. Following productive VHDJH gene rearrangement in the Ig heavy-chain gene complex, mu-heavy chain is the first Ig gene product expressed in cells committed to the B-lymphoid differentiation pathway. Interleukin ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2003
ISSN: 0021-9258
DOI: 10.1074/jbc.m300022200